Start a new project named Cryptogram. Build the form as shown below:

Write the code as shown below:
Public Class Form1
Private Sub BtnGo_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles BtnGo.Click
Dim Alphabet As String = "ABCDEFGHIJKLMNOPQRSTUVWXYZ"
Dim Code As String = Scramble(Alphabet)
Me.Text = Code
Dim S As String = Me.TxtWords.Text
S = S.ToUpper
Dim S2 As String = ""
Dim I, Pos As Integer
For I = 0 To S.Length - 1
Dim Ch As Char = S.Substring(I, 1) 'get 1 character from S
Pos = Alphabet.IndexOf(Ch)
If Pos >= 0 Then
S2 += Code.Substring(I, 1) 'get the corresponding character from code
Else
S2 += Ch 'if not a letter, do not encode it
End If
Next
Me.TxtCryptogram.Text = S2
End Sub
Private Function Scramble(ByVal S As String) As String
Dim Ch As Char()
Ch = S.ToCharArray()
Dim I As Integer
For I = 0 To Ch.Length - 1
Dim R As Integer = Int(Rnd() * Ch.Length)
Dim Temp As Char = Ch(I)
Ch(I) = Ch(R)
Ch(R) = Temp
Next
Dim S2 As String = ""
For I = 0 To Ch.Length - 1
S2 += Ch(I)
Next
Return S2
End Function 'Scramble
Private Sub Form1_Load(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles MyBase.Load
Randomize()
End Sub
End Class
Experiment! You can make lots of games like hangman, fortune, etc. that use strings.